💡An integrated offering for your preclinical studies
The members of the network offer a complete range of services to structure, conduct and enhance preclinical studies, from protocol design to interpretation of results. Our teams mobilize their expertise in numerical modeling, biological experimentation and functional analysis, to meet the validation requirements of devices prior to their use in humans.
Our expertise
💻 Digital modeling & simulation:
- Supercomputers for complex calculations and production of synthetic biomarkers (ECG....)
- Development of digital twins of the heart
- In silico testing of medical or biological hypotheses
- Multiscalar modeling
- Non-invasive electrocardiographic imaging(ECGi)
🧪 In vitro experimentation, ex vivo & in vivo :
- In vitro: Cytocompatibility and cytotoxicity tests (ISO 10993, ASTM on request), advanced cellular techniques (confocal microscopy, microspectrofluorimetry, bioenergetic analyses), exploration of neuronal and muscular mechanisms in various models (Drosophila, C. elegans, zebrafish, chicken, mouse, human)
- Ex vivo: Functional tests on isolated-perfused heart models, optical mapping of electrical activation, histological, immunohistochemical, histo-morphometric analyses, scanning electron microscopy (SEM), tests on human tissues and animal models
- In vivo: Biocompatibility (ISO 10993) and biofunctionality studies, proof-of-concept in animal models, clinical and biological follow-up
💓 Signal analysis & algorithm development:
- Instrumentation and processing of electrophysiological signals (ECG, EGM, intracardiac mapping).
- Development of customized analysis tools, Simulation/experimentation interface
📊 Technical, functional and usage evaluation:
- Preclinical technical evaluation (robustness, efficacy)
- Advanced functional evaluation (pathophysiology studies, proof of concept)
- Tests on human cadavers, simulation models (mannequin, in silico, in virtuo)
- Ergonomic and usability evaluation (fitness for purpose, ISO 62366-1)
🔑The CIC-IT, key network partners
The network also relies on several specialized CIC-ITs, which play a structuring role in supporting technological innovations:
- In cardiovascular pathologies (atrial fibrillation, amyloidosis)
- In implantable biomaterials and medical devices
On implantable devices and massive data in cardiology
- In robotics and image-guided therapies
Our state-of-the-art infrastructures
The network relies on its member establishments (CIC-IT, clinical centers, IHU) equipped with reference preclinical platforms, high-performance facilities and equipment, including:
- Scientific platforms and specialized laboratories in animal electrophysiology, reproducing the conditions of clinical intervention rooms, genetics, advanced imaging, in vivo experimentation, cellular electrophysiology, neuromuscular systems, digital modeling and simulation, electrophysiological signal processing, ultrasound and applied mechanics....
- Advanced medical imaging technologies Research MRI, photon-counting scanner, intraoperative 3D imaging, augmented reality advanced imaging with MRI from 1.5 to 9.4T, ect
- Modeling and experimental platforms dedicated to interventional electrophysiology.
- Bioengineering facilities, including for example: fundamental research on cardiac neural networks (optogenetic techniques, iDISCO, Langendorff, biochemistry), surgical simulator on circulating human cadaveric model, infrastructure dedicated to clinical and preclinical image collection and analysis, prototyping platform..
